Artificial Intelligence in Drug Discovery and Development Nptel Week 4 Answers
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AI in Drug Discovery and Development Week 3 Answers (July-Dec 2025)
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Question 1. What is the main purpose of pilot plant operations in drug scale-up?
a) To perform drug marketing studies
b) To conduct full-scale manufacturing directly
c) To test reaction kinetics, equipment feasibility, and reproducibility
d) To design drug packaging
Question 2. Which of the following statements is true about competitive enzyme inhibition?
a) It cannot be overcome by increasing substrate concentration
b) The inhibitor binds to an allosteric site
c) It increases enzyme activity
d) The inhibitor resembles the substrate and competes for the active site
Question 3. Which enzyme class catalyzes the hydrolysis of chemical bonds?
a) Ligase
b) Isomerase
c) Transferase
d) Hydrolase
These are AI in Drug Discovery and Development Week 4 Answers
Question 4. Which of the following is the correct order of the omics-based target validation cycle?
a) Drug Development → Target Optimization → Omics Data Collection
b) Omics Data Collection → Target Identification → Target Validation → Target Optimization → Drug Development
c) Target Identification → Omics Data Collection → Drug Development → Target Validation
d) Target Validation → Target Optimization → Omics Data Collection
Question 5. Which study type is best suited for early-stage, cost-effective screening of compounds?
a) In Vivo
b) In Vitro
c) In Silico
d) Ex Vivo
Question 6. Which technique involves partially reducing gene expression to validate a target?
a) Gene Knockout
b) Chemical Probing
c) Gene Knockdown
d) Gene Editing
Question 7. What does the DeepSEA tool predict in drug discovery?
a) Drug toxicity levels
b) Gene expression regulation
c) Chromatin effects of sequence variations
d) Metabolic pathways
Question 8. What is the primary function of the TripletGO AI tool in omics?
a) Image analysis in pathology
b) Predicting gene functions using expression profiles and homology
c) Drug discovery using phenotypic similarity
d) Annotating single-cell RNA-seq data
These are AI in Drug Discovery and Development Week 4 Answers
Question 9. Which multi-omics database focuses on gene expression across human tissues, including sex-based differences?
a) TCGA
b) MetaboLights
c) ProteomicsDB
d) GTEx program
Question 10. What role does transcriptomics play in drug target discovery?
a) Detecting post-translational modifications
b) Measuring protein abundance
c) Revealing gene expression differences between tissues
d) Identifying metabolite spectra
Question 11. Which genomic approach identifies genetic variants linked to diseases?
a) WES
b) WGS
c) GWAS
d) Comparative genomics
Question 12. Which AI tool uses a CNN-based approach to analyze 3D protein structures?
a) SiteMap
b) DeepSite
c) P2Rank
d) AlphaFold
These are AI in Drug Discovery and Development Week 4 Answers
Question 13. What input does AlphaFold require to predict protein structures?
a) X-ray images
b) Evolutionary data
c) Amino acid sequence
d) Cryo-EM data
Question 14. What is a limitation of protein language models compared to MSA-based models?
a) Slower prediction time
b) Requires evolutionary information
c) Lower accuracy for well-characterized proteins
d) Cannot use transformer architectures
Question 15. Which of the following is a computational method for determining protein structure?
a) Cryo-EM
b) X-ray crystallography
c) Homology modeling
d) NMR
These are AI in Drug Discovery and Development Week 4 Answers